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  3. 天然物有機金屬化學研究領域

 

天　然　物、　有　機　金　屬　化　學　研　究　領　域
研究領域名稱
  • 天然藥物化學、有機金屬化學、藥物化學研究領域
計畫執行參與教師
  • 潘文彬副教授

  • 魏麗梅副教授

  • 魏麗蘭副教授
研究發展概況說明
  • 利用有機金屬鈰錯合物進行有機反應並探討反應機轉。

  • 研究中草藥的化學組成及其活性，利用各種層析及光譜技術分離、 純化及鑑定化學結構。必要時再進行化學反應及合成以助結構之確認。
歷年研究主題
  • 鈀金屬錯合物催化苯甲醛類似物的新奇氧化反應
  • 鈀催化三級丙炔醇和芳香基碘化物芳香基化/重排反應的探討
  • 屏東笠頂山山藥活性成分之研究
  • 硝酸銨鈰促使炔類化合物自由基氧化反應及生物活性的探討
研究成果

A、期刊論文

  1. W. B. Pan; F. R. Chang; Y. C. Wu*, “Tupichigenin A, a new steroidal sapogenin from Tupistra chinensis” J. Nat. Prod., 2000, 63(6), 861-863. (SCI)
  2. W. B. Pan; F. R. Chang; Y. C. Wu*, “Spirostanol Sapogenins from the Underground Parts of Tupistra chinensis” Chem. Pharm. Bull., September, 2000, 48(9), 1350-1353. (SCI)
  3. C. Y. Chen; F. R. Chang; W. B. Pan; Y. C. Wu*, “Four New Alkaloids from Annona cherimola” Phytochemistry, 2001, 56(7), 753-757. (SCI)
  4. R. Patnam; F. R. Chang; R. Y. Kuo; W. B. Pan; Y. C. Wu*, ”Microwave enhanced acetylation of alcohols” J. CHEM. RESEARCH, 2002, 301-302. (SCI)
  5. W. B. Pan; F. R. Chang; L. M. Wei; M. J. Wu; Y. C. Wu*, “New and efficient method for esterification of carboxylic acids with simple primary and secondary alcohols using cerium(IV) ammonium nitrate (CAN) “, Tetrahedron Letters, 2003, 44 (2), 331-334. (SCI)
  6. L. M. Wei; L. L. Wei; W. B. Pan; M. J. Wu*, “Palladium-catalyzed ring expansion of 1-alkynylcyclobutanols with aryl iodides: an efficient route to 2-disubstituted methylenecyclopentanones”, Tetrahedron Letters, 2003, 44 (3), 595-597. (SCI)
  7. L. L. Wei; L. M. Wei; W. B. Pan; M. J. Wu*, “Selective reduction of alkynes catalyzed by palladium acetate with sodium methoxide as the hydride source”, Tetrahedron Letters, 2003, 44(9), 1979-1981. (SCI)
  8. W. B. Pan; F. R. Chang; L. M. Wei; Y. C. Wu*, “New Flavans, Spirostanol Sapogenins, and a Pregnane Genin from Tupistra chinensis and Their Cytotoxicity “, J. Nat. Prod., 2003, 66, 161-168. (SCI)
  9. L. L. Wei; L. M. Wei; W. B. Pan; M. J. Wu*, 2004, 9, “Palladium-Catalyzed Esterification-Hydroarylation Reactions of 2-Alkynylbenzaldehydes with Aryl iodides in Methanol”, Synlett,1497-1502. (SCI)
  10. W. B. Pan; L. M. Wei; L. L. Wei; C. C. Wu; Y. C. Wu*, 2005, 52,“Esterification-nitration of ortho-hydroxylphenyl carboxylic acids and benzoic acids with cerium(IV) ammonium nitrate (CAN) “, J. Chin. Chem. Soc., 173-180. (SCI)
  11. W. B. Pan; L. M. Wei; L. L. Wei; C. C. Wu; F. R. Chang; Y. C. Wu*, “Nitrophenol derivatives oxidized by cerium(IV) ammonium nitrate (CAN) and their cytotoxicity”, J. Chin. Chem. Soc., 2005,52 (3), 581-588. (SCI)
  12. L. M Wei; L. L. Wei; W. B. Pan; M. J. Wu*, “ Synthesis of Tetraarylallenes via Palladium-Catalyzed Addition-Elimination Reactions of 1﹐1﹐3-Triary1-2-propyn-l-ols with Aryl Iodides ”, Synlett. 2005, 14. 2219-2223. (SCI)
  13. W. B. Pan; L. M Wei; L. L. Wei; Y. C. Wu*, “Chemical Constituents of Tupistra chinensis Rhizomes” Chem. Pharm. Bull., 2006, 54(7), 954-958. (SCI)

B、研討會論文

  1. W. B. Pan, L. M. Wei, L. L. Wei, 1996, “Photo-induced Electron Transfer Reactions in Ruthenium-Iron Double Complexes’’,中國化學會八十五年年會學術研討會論文摘要, Taiwan.
  2. W. B. Pan, L. M. Wei, L. L. Wei, 1997, “Study on Lead and Cadmium Concentrations in Groundwater on Dah-Liau Area”,中國化學會八十六年年會,學術研討會論文摘要, Taiwan.
  3. W. B. Pan, F. R. Chang, Y. C. Wu, 1998, “Novel Steroidal Sapogenins from Euphorbia helioscopia L.”,中國化學會八十七年年會,學術研討會論文摘要, Taiwan.
  4. W. B. Pan, F. R. Chang, Y. C. Wu, 1999, “Spirostanol Saponin and Sapogenins from Tupistra chinensis B.”,中國藥學會八十八年年會暨藥學學術研討會論文摘要, December 18, Taiwan.
  5. W. B. Pan, F. R. Chang, Y. C. Wu, 1999, 11, “Steroidal Saponin and Sapogenin from Euphorbia helioscopia L.”,中國化學會八十八年年會,學術研討會論文摘要, P.147, P-OR-031, Taiwan.
  6. W. B. Pan, F. R. Chang, Y. C. Wu, 1999, 11, “Steroidal Saponin And Sapogenin from Euphorbia helioscopia L.”, The 8th Asia Chemical Congress And Chemical Industry& Instrumental Exhibition, ABSTRACTS,P.59, November 21-24, Taiwan.
  7. W. B. Pan, F. R. Chang, Y. C. Wu, 2000, 11, 4, “New Flavans from Tupistra chinensis”,第十五屆天然藥物研討會,論文摘要,P.105, 106, Taiwan.
  8. W. B. Pan, F. R. Chang, Y. C. Wu, 2000, 11, “New Spirostanol Sapogenin from Tupistra chinensis”,中國化學會八十九年年會,學術研討會論文摘要, PC-45, Taiwan.
  9. W. B. Pan, F. R. Chang, Y. C. Wu, 2001, 12, 29 “New Steroidal Sapogenin and Pregnan Genin from Tupistra chinensis and Their Cytotoxicity”,中國化學會九十年年會,學術研討會論文摘要, OR-23,國立成功大學, Taiwan.
  10. F. R. Chang, W. B. Pan, L. M. Wei, Y. C. Wu, 2002, “New Steroidal Sapogenin and Pregnan Genin from Tupistra chinensis and Their Cytotoxicity”, International Congress and 50th annual Meeting of the Society for Medicinal Plant research (GA), September 8-12, Barcelona, Spain.
  11. W. B. Pan, F. R. Chang, L. M. Wei, M. J. Wu, Y. C. Wu, 2002, 12, 21, 22 “New method for the esterification of carboxylic acids using cerium(IV) ammonium nitrate (CAN)”,中國藥學會九十一年會暨藥學學術研討會,學術研討會論文摘要,大仁技術學院 PC-06, P.134, Taiwan.
  12. M. J. Wu, L. L. Wei; L. M. Wei; W. B. Pan, “Palladium-Catalyzed Esterification-Hydroarylation Reactions of 2-Alkynylbenzaldehydes with Aryl iodides in Methanol” Japan, Fifteenth Internation Conference on Organic Synthesis (IUPAC ICOS-15 ) 2004, 5-D-20.
  13. W. B. Pan, L. M Wei; L. L. Wei; F. R. Chang; Y. C. Wu, “ A New Pregane Glycoside, A New Natural Occurrence Lignan, and Other Chemical Constituents from the Rhizomes of Tupistra chinesis” 行政院衛生署中醫藥委員會九十二年度中醫藥研究成果發表會暨第十九屆天然藥物研討會, 高雄醫藥大學, P-73, 2004.
  14. L. L. Wei; L. M Wei; W. B. Pan; M. J. Wu “Palladium-Catalyzed Esterification-Hydroarylation Reactions of 2-Alkynylbenzaldehydes with Aryl Iodides in Methanol ” 中國化學會93年會學術研討會, 中興大學, ORS-B-114, 2004.
  15. L. M Wei; L. L. Wei; W. B. Pan; M. J. Wu “ Synthesis of Tetraarylallenes via Palladium-Catalyzed Simultaneous Addition-Elimination Reactions of 1﹐1﹐3-Triary1-2-propyn-l-ols with Aryl Iodides ” 中國化學會93年會學術研討會, 中興大學, ORS-B-113, 2004.
  16. W. B. Pan; L. M Wei; L. L. Wei; Y. C. Wu, “ Phenol and Nitrophenol Derivatives Oxidized by Cerium(IV) Ammonium Nitrate (CAN) and their Cytotoxicities toward Human Hepatocellular and Breast Carcinoma Cells ” 中國化學會93年會學術研討會, 中興大學, ORS-B-112, 2004.
  17. W. B. Pan; L. M Wei; L. L. Wei; Y. C. Wu, “ Nitration-Esterification of ortho-Hydroxyphenyl Carboxylic Acids and Benzoic Acids with Cerium(IV) Ammonium Nitrate (CAN)” 中國化學會93年會學術研討會, 中興大學, ORS-B-111, 2004.
  18. W. B. Pan; L. M. Wei; L. L. Wei; Y. C. Wu, “ Flavonoids and Alkaloids from the Rhizomes of Tupistra??? chinensis” 中國藥學會94年會學術研討會, 嘉南藥理科技大學, PA-21, 2005.
  19. W. B. Pan; L. M. Wei; L. L. Wei; L. H. Chang; Y. C. Wu, “ New Spirostanol Saponins from the Rhizomes of Tupistra chinesis” 行政院衛生署中醫藥委員會九十四年度委辦研究計畫成果發表會暨第二十一屆天然藥物研討會, 中國醫藥大學, P-388, 2006.
共同參與研究人員
　 (含研究生)
  • 李美欣、李翠娟、洪震寧、陳仲豪